Bioprogramming the Behaviour of Nanoparticles in Live Cells by Nanoscopy

Ultrasound-Driven Coassembly of Anticancer Drugs into Carrier-Free Particles

M Mohankumar, S Fernandes, F Cavalieri, C Cortez-Jugo, F Caruso

2025-04-08

The evolution of drug resistance in tumor malignancies has necessitated advancements in anticancer drug therapy. Drug combination ..

Trafficking Glycogen Nanoparticles through Lymph Node Tissues for the Delivery of Small and Large Bioactive Molecules

S Fernandes, R Xu, R De Rose, Y Gu, A Dominicis, SK Bhangu, H Mahmoudinoodezh, H Zhu, G Forte, CE Hagemeyer, F Caruso, F Cavalieri

2025-01-01

Targeted delivery of therapeutics to lymph nodes (LNs) via minimally invasive subcutaneous injection offers promise to treat B and..

NMR techniques for investigating antimicrobial peptides in model membranes and bacterial cells

Marc-Antoine Sani, Sunnia Rajput, David W Keizer, Frances Separovic

2024-04-01

AMPs are short, mainly cationic membrane-active peptides found in all living organism. They perform diverse roles including signal..

Tracking the Endosomal Escape of Nanoparticles in Live Cells Using a Triplex-Forming Oligonucleotide

Sukhvir Kaur Bhangu, Liviana Mummolo, Soraia Fernandes, Alessia Amodio, Agata Radziwon, Brendan Dyett, Marco Savioli, Nitin Mantri, Christina Cortez-Jugo, Frank Caruso, Francesca Cavalieri

2024-01-01

Nanoparticle-mediated intracellular delivery of oligonucleotides is a complex phenomenon that depends on the architecture and the ..

The membrane activity of the antimicrobial peptide caerin 1.1 is pH dependent

MA Sani, AP Le Brun, S Rajput, T Attard, F Separovic

2023-03-21

Antimicrobial peptides are an important class of membrane-active peptides that can provide alternatives or complements to classic ..

Supramolecular Assembly of Polyphenols and Nucleic Acids by Thermal Cycling for Immune Cell Activation

Yijiao Qu, Haiyan Zhu, Zhixing Lin, Domitilla Vanni, Sukhvir Kaur Bhangu, Brendan Dyett, Marc-Antoine Sani, Christina Cortez-Jugo, Frank Caruso, Francesca Cavalieri

2023-01-01

Supramolecular assembly of polyphenols and biomacromolecules (proteins and nucleic acids) has emerged as a versatile and simple st..

In-cell DNP NMR reveals multiple targeting effect of antimicrobial peptide

F Separovic, V Hofferek, AP Duff, MJ McConville, MA Sani

2022-01-01

Dynamic nuclear polarization NMR spectroscopy was used to investigate the effect of the antimicrobial peptide (AMP) maculatin 1.1 ..